In December 2019, Wuhan, China was the first reported coronavirus disease. It spread all over the world and become a global pandemic. It affects around every country in the world. It affects unprecedented public health. It also affects social and economic activity. The patience of COVID-19 is increased day by day over the last 6 months around the world. There is no prevention is available across the world. The genus beta coronavirus mainly caused the COVID-19. The other two coronaviruses are also caused by the pandemic situations in the world which are (SAR-COV) severe acute respiratory coronavirus and (MERS-CoV) middle east respiratory syndrome coronavirus. COVID-19 causes respiratory infection. It also shows pneumonia and acute respiratory distress syndrome (ADRs). These coronaviruses may trigger cytokine storms like tumor necrosis, IL-β, IL-6, etc. which may release by the immune system and it can form multiorgan failure. These may form coagulations in a proportional substantial in patients. It can form thromboembolic events. The biological features show that 79.6% of genomic sequences is been identified. It shows that both the diseases may enter the body in the same way and it may trigger the binding of viral spike (S) protein to ACE2 in the host cells. Clinical data shows that the susceptibility to the COVID-19 is strongly associated the cardiovascular diseases. These may observe in many COVID-19 patients and it may increase the comorbidities and mortality rate. It also forms myocardial injury, acute coronary syndrome, and thromboembolism. Children have also been affected by COVID-19. It forms hyperinflammatory shock. It also has cardiac dysfunction and coronary vessel abnormalities. It shows bidirectional interaction between the cardiovascular system and COVID-19. This mechanism is elusive. de novo cardiovascular damage is developed in subclinical disorder. For the virus entry ACE2, surface protein plays a most important role. RAAS (renin-angiotensin-aldosterone system) also shows the interaction. Pathophysiology plays a most important role in the development of therapies. Around 45 to 50 million coronavirus cases are crossed. It may kill around 1.2 to 1.5 million people. Dyspnea, respiratory frequency, blood oxygen saturation, and arterial pressure symptoms are also seen in patients. Some cases of COVID-19 may show respiratory failure and mechanism ventilation, shocks, and coagulopathy. Immunopathology is helpful for the identification of clinician patients who shows a higher risk and it may require prioritized treatment for the progression and adverse outcome. In demographic risk factors age, sex, and ethnicity complication play an important role. Some risk factor is been shown to be the high risk of illness. The cellular serine protease (TMPRSS2) is been formed. These are implicated in cancer and viral infections. the ACE2 is been expressed in alveolar cell type 2. It also presents on endothelial and smooth muscle cells. The paucisymptomatic and asymptomatic show a substantial fraction in COVID-19 with comorbidities. It shows acute respiratory failure, cytokine storm, prothrombotic, organ dysfunction, and death. Cancer patients have more susceptible to COVID-19 as compared to non-cancer patients. Cancer risk factors show a high prevalence of COVID-19. CT (computed tomography) is used for metabolic disorders. Some countries have patient which is diagnosed with cancer and have a small amount of COVID-19 infections. cancer prevalence is not associated with infection risk. Lung carcinoma is been shown in CT scan manifestations. Gender shows the main risk factor in the population. Obesity and congestive heart failure are one of them. For the association of COVID-19 race and ethnicity also play a most important role. Hispanic and black people are most affected by this disease. Veneto region shows a higher number of COVID-19 patients and death. The hematology lungs and breast cancer show the more vulnerable as compared to cancer patients. Coronavirus mostly affected lung cancer patients. For this type of person, coronavirus shows more infections. severity is for pulmonary disease patients. The comorbidities is been increased for former smokers and chemotherapy patients. At older age the hematological malignancies were diagnosed as myeloid leukemia and plasma cell neo plasma was associated with worse. The more susceptible patients with metastatic or stage IV carcinomas is been diagnosed with COVID-19. The severity of the cancer treatment is been contributed to the cancer patient. In the multivariant analysis of patients, the age and receipt of immune inhibitor treatment is been associated with COVID-19 patients. In this only 2.5% of patients is been seen as positive. Age is the most important factor in COVID-19 patients. It was not clear whether the cancer is a more risk factor or the cancer-associated risk depends on demography. Cancer diagnosis and COVID-19 are more dangerous to the risk of death. The cancer cohorts are well described in the meta-analysis of COVID-19 patients.